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Optimal Selection Feline
Optimal Selection Feline
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Optimal Selection™ Feline Genetic Breeding Analysis

PRICE: $99.99


Cats can’t talk but their DNA can™.

Wisdom Health, makers of the Optimal Selection™ Breeder Analysis have partnered with Genoscoper Laboratories® of Finland to provide breeders with the most comprehensive test of its kind. Wisdom Health has taken the latest scientific research on feline population genetics and developed a simple at –home swab test that screens for multiple diseases and traits. This kind of testing can help breeders develop proactive, sustainable breeding programs.

The Optimal Selection Feline Breeder Analysis provides:

  • Results for over 40 genetic diseases, reported in terms of known relevance to the specific breed evaluated.
  • Testing for 20+ traits including blood type, coat colors, coat types, and morphology.
  • Genetic diversity information for the tested cat, the overall breed population, and related breed groups.

Optimal Selection also provides:

  • A customizable profile for each cat on the international online breeder portal that can be shared, transferred to a new owner, or kept private.
  • Tools to connect breeders with other fanciers of their breed worldwide that may expand their breeding options.
  • Continuously updated research and breed information based on the discoveries from the Optimal Selection Feline database of genetic submissions.  
  • A Breeder Tool to help breeders identify potential mates, using cutting-edge analysis looking at diversity and health results.

To see a sample report, click here.


Optimal Selection tests for many coat colors and patterns, coat types, and morphologic (conformational) traits. Results are displayed in an easy-to-understand chart. Traits tested for include:

Blood Type

  • Blood Type B - c.268T>A & c.179C>T
  • Blood Type AB (found in Ragdoll)

Brown - B Locus

  • Cinnamon
  • Chocolate

Agouti – A Locus

  • Non-agouti
  • Charcoal

Dilution – D Locus

Extension – E Locus

  • Amber variant - found in Norwegian Forest Cat
  • Russet variant - found in Burmese

Color Points

  • Siamese variant
  • Burmese variant
  • Albino variant

Dominant White and White Spotting – W Locus

Birman White Gloves (for Birman only)

Long Hair

  • Mutation FGF5: c.475A>C
  • Mutation FGF5: c.406C>T
  • Mutation FGF5: c.ins356T
  • Mutation FGF5: c.474delT

Coat Type

  • Selkirk Rex Coat
  • Cornish and German Rex Coat
  • Devon Rex Coat (for Sphynx only)


Short Tail

  • Japanese bobtail
  • Manx bobtail: c.T998del
  • Manx bobtail: c.T1169del
  • Manx bobtail: c.T1199del


  • LIMBR1: c.A479G
  • LIMBR1: c.G257C
  • LIMBR1: c.A481T


Optimal Selection™ is a unique multipurpose test. Instead of series of one-off tests for diseases and individual mutations, Optimal Selection delivers a comprehensive set of results for 40 genetic diseases. However, because not all gene variants cause disease in each breed, and most disease variants have not been investigated in all breeds, detailed information about the test results are provided in three categories:

  1. Disorders known to be relevant to the tested breed
  2. New potential disorders
  3. Other disorders, usually ones not found to be significant in the breed

As genetic samples are collected and new potential disorders become known, they are listed only after certain criteria have been met to suggest they may be of significance in the breed:

  1. The result is verified by a secondary technology
  2. Clinical confirmation is obtained

Once these criteria have been met, the condition is listed as a new potential disorder in the breed and additional follow-up and analysis is performed. In this way, Optimal Selection users—through their sample submissions—help with ongoing research, and help participate in early surveillance for disorders that may be spreading in the population.

Following is a list of diseases that are covered by Optimal Selection. Note that not every disease is applicable to every breed.

Acute Intermittent Porphyria; HMBS mutation c.107_110delACAG
Acute Intermittent Porphyria; HMBS mutation c.826-1G>A
Acute Intermittent Porphyria; HMBS mutation: c.189dupT
Acute Intermittent Porphyria; HMBS mutation: c.844delGAG
Autoimmune Lymphoproliferative Syndrome
Bengal Progressive Retinal Atrophy (PRA-b)
Blood-brain Barrier Dysfunction, MDR1 / ABCB1
Burmese Head Defect; ALX1 mutation
Chylomicronemia, Lipoprotein Lipase Deficiency
Congenital Adrenal Hyperplasia
Congenital Erythropoietic Porphyria; UROS mutation: c.331G>A
Congenital Hypotrichosis with Short Life Expectancy
Congenital Myasthenic Syndrome (CMS)
Cystinuria; SCL3A1 mutation
Cystinuria; SCL7A9 mutation: c.1175C>T
Cystinuria; SCL7A9 mutation: c.706G>A
Cystinuria; SCL7A9 mutation: c.881A>T
Factor XII Deficiency
Glycogen Storage Disease Type IV
GM1 Gangliosidosis
GM2 Gangliosidosis, Domestic Shorthair HEXB mutation: c.1467_1491inv
GM2 Gangliosidosis, Japanese Domestic HEXB mutation: c.667C>T
GM2 Gangliosidosis; Domestic Shorthair GM2A mutation
Hemophilia B; F9 mutation: c.1014C>T
Hemophilia B; F9 mutation: c.247G>A
Hypertrophic Cardiomyopathy found in Maine Coon
Hypertrophic Cardiomyopathy found in Ragdoll
Mucopolysaccharidosis Type I (MPS I)
Mucopolysaccharidosis Type VI (MPS VI), Typical Form
Mucopolysaccharidosis Type VII; GUSB mutation: c.1074G>A
Mucopolysaccharidosis VII; GUSB mutation: c.C1424T
Myotonia Congenita
Niemann-Pick C1, NPC Disease, Sphingomyelinosis; NPC1 mutation: c.2865G>C
Niemann-Pick C2, NPC Disease, Sphingomyelinosis; NPC2 Mutation
Osteochondrodysplasia and Folded Ears; TRPV4 mutation
Periodic Hypokalemic Polymyopathy, Burmese Hypokalemia, or Familial Episodic Hypokalaemic Polymyopathy
Polycystic Kidney Disease
Pyruvate Kinase (PK) Deficiency
Retinal Dystrophy (rdAc)
Spinal Muscular Atrophy (SMA)/Spinal Muscular Dystrophy
Vitamin D-Dependent Rickets (VDDR-1A); CYP27B mutation: c.G637T


Why genetic diversity? Genetic diversity is essential for survival of a species, and can be thought of as the breed’s "tool kit" for this purpose. Breeding for genetic diversity may help to:

  • Decrease the incidence of kittens affected with recessively inherited diseases and diseases influenced by multiple genes.
  • Increased litter sizes.
  • Provide defense against diseases of unknown or complex genetic basis that cannot be otherwise addressed, until research finds the genetic cause.

Breeding for genetic diversity is an investment in the future health of the breed. Optimal Selection provides information on the diversity in three ways:

  1. Diversity of the individual cat tested.
  2. Diversity of the overall breed population.
  3. Diversity of the overall breed population compared to the diversity of other related breed populations.

Breeder Tool™

To help breeders navigate the complexities of breeding for type, health, and diversity, Optimal Selection offers breeders the world's first matchmaking tool. The Breeder Tool distills all the results information on the health, traits, and diversity of the cats from each breed population in the Optimal Selection database and provides a scientifically-calculated compatibility score for possible mates. The score helps to identify the breeding pairs that are most likely to produce the healthiest, most diverse kittens.

Breeders can use this information, in addition to criteria like temperament, conformation of the cat, etc. in making mating decisions. Unlike pedigree analysis or coefficient of inbreeding analysis, the Breeder Tool considers each cat as an individual, evaluating more than 7,815 data points to generate the compatibility scores. The markers were carefully selected to measure genome-wide variation and represent each chromosome equally which may have advantages over traditional techniques like pedigree analysis.


Can the results be transferred to my breed registry?

DNA profiling is the primary type of DNA testing offered by breed registries in the US. DNA profiling is for the purpose of permanent identification of a cat (similar to a microchip) and for parentage testing; it does not screen for genetic diseases or genetic diversity. DNA profiling typically uses 9 microsatellite markers (often called STRs) to identify each cat, which are a different type of DNA marker than the one used in the Optimal Selection Feline DNA test. Because different markers are used, in significantly greater numbers, and at different locations than those used in DNA profiling, results are not equivalent or transferrable. While Optimal Selection was not designed for DNA profiling for the purposes of verifying parentage or cat identity, it does identify every cat tested as a unique and recognizable individual.

Can I test kittens?
Yes! Kittens can be tested, as their DNA results do not change with age. However, care must be taken that the queen’s or littermates’ DNA does not contaminate the sample. The process of nursing seeds the kitten’s mouth with DNA from the queen’s skin and the cells in her milk, so we do not recommend testing kittens who are still nursing. However, as soon as kittens are weaned, they can be safely tested following the usual guidelines. Optimal Selection feline profiles and accompanying results are designed to be easily shared or transferred to new owners when needed, free of charge, so an entire litter can be listed with Optimal Selection before they leave their birth home.

What breeds do you test for?

All breeds can be tested using an Optimal Selection DNA test and receive results about individual genetic health. However, certain breed statistics will not become available until a minimum number of individuals of that breed have been tested, in order to provide statistically significant population results.

Should I test my mixed-breed cat using Optimal Selection?
No. Optimal Selection is intended for pedigreed cats only.

Are results shared with registries or other breeders?
No. Wisdom Health takes client confidentiality seriously and does not share testing information. Identities of submitting owners, as well as individual testing results, are not visible to anyone but the submitting owner, unless the owner chooses to share that information.

Can I submit semen from a deceased cat?
Yes. The Optimal Selection Feline Genetic Breeding Analysis test is typically performed on cheek swab DNA samples. However, semen samples are also an excellent source of DNA if the cat is not available for swabbing.  Note that a small additional laboratory processing fee is required for semen samples.

The preferred semen sample is in the form of semen straws. However, pellets, vials or tubes of semen are also acceptable. A minimum of 50 microliters of semen is required for testing, although we recommend sending at least 100 microliters to ensure a sufficient quantity for testing. The volume contained in a semen straw varies, but any fully loaded straw will have more than the minimum 50 microliter volume.

Please contact Customer Service for a step-by-step guide to submit this sample type at or 888-597-3883 and they would be happy to help you.



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