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Optimal Selection Feline
Optimal Selection Feline
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Optimal Selection™ Feline Genetic Breeding Analysis

PRICE: $99.99


Cats can’t talk but their DNA can™.

Wisdom Health, makers of the Optimal Selection™ Breeder Analysis have partnered with Genoscoper Laboratories® of Finland to provide breeders with the most comprehensive test of its kind. Mars Veterinary has taken the latest scientific research on feline population genetics and developed a simple at –home swab test that screens for multiple diseases and traits. This kind of testing can help breeders develop proactive, sustainable breeding programs.

The Optimal Selection Feline Breeder Analysis provides:

  • Results for 30+ genetic diseases, reported in terms of known relevance to the specific breed evaluated.
  • Testing for 15+ traits including blood type, coat colors, coat types, and morphology.

Optimal Selection also provides:

  • A customizable profile for each cat on the international online breeder portal that can be shared, transferred to a new owner, or kept private.
  • Tools to connect breeders with other fanciers of their breed worldwide that may expand their breeding options.
  • Continuously updated research and breed information based on the discoveries from the Optimal Selection Feline database of genetic submissions.  
  • A breeder tool to help breeder identify potential mates.

To see a sample report, click here.


Optimal Selection tests for many coat colors and patterns, coat types, and morphologic (conformational) traits. Results are displayed in an easy-to-understand chart. Traits tested for include:

Blood Type
Brown - B Locus

  • Cinnamon
  • Chocolate

Agouti – A Locus
Dilution – D Locus
Amber – E Locus
Color Points

  • Siamese variant
  • Burmese variant

White Gloves
Long Hair

  • Mutation FGF5: c.475A>C
  • Mutation FGF5: c.406C>T
  • Mutation FGF5: c.ins356T

Coat Type

  • Curly (Rexing/Woolly)

Short Tail
l (2 mutations)



Optimal Selection™ is a unique multipurpose test. Instead of series of one-off tests for diseases and individual mutations, Optimal Selection delivers a comprehensive set of results for more than 30 genetic diseases. However, because not all gene variants cause disease in each breed, and most disease variants have not been investigated in all breeds, detailed information about the test results are provided in three categories:

  1. Disorders known to be relevant to the tested breed
  2. New potential disorders
  3. Other disorders, usually ones not found to be significant in the breed

As genetic samples are collected and new potential disorders become known, they are listed only after certain criteria have been met to suggest they may be of significance in the breed:

  1. The result is verified by a secondary technology
  2. Clinical confirmation is obtained

Once these criteria have been met, the condition is listed as a new potential disorder in the breed and additional follow-up and analysis is performed. In this way, Optimal Selection users—through their sample submissions—help with ongoing research, and help participate in early surveillance for disorders that may be spreading in the population.

Following is a list of diseases that are covered by Optimal Selection. Note that not every disease is applicable to every breed. Please be aware that, due to differences in laws by country, this test list applies to US customers only. For international inquiries, please contact us for more information.

Acute Intermittent Porphyria, HMBS: Site 844 mutation
Blood-Brain Barrier Dysfunction, MDR1 / ABCB1
Chylomicronemia or Lipoprotein Lipase Deficiency
Congenital Adrenal Hyperplasia
Congenital Erythropoietic Porphyria, UROS: Site 331 mutation
Congenital Hypotrichosis and Short Life Expectancy
Congenital Myasthenic Syndrome (CMS)
Cystinuria, SLC7A9: Site 1175 mutation
Cystinuria, SLC7A9: Site 706 mutation
Erythrocyte Pyruvate Kinase (PK) Deficiency
Factor IX Deficiency or Hemophilia B (HEMB); Site 1014 Mutation
Factor IX Deficiency or Hemophilia B (HEMB); Site 247 Mutation
Factor XII Deficiency
Feline GM1 Gangliosidosis
Feline GM2 Gangliosidosis or Sandhoff Disease; HEXB Burmese Mutation
Feline GM2 Gangliosidosis or Sandhoff Disease; HEXB Japanese Domestic Mutation
Feline GM2 Gangliosidosis or Sandhoff Disease; HEXB Korat Mutation
GM2 Gangliosidosis; GM2A Mutation
Hypertrophic Cardiomyopathy (HCM) found in Maine Coon
Hypertrophic Cardiomyopathy (HCM) found in Ragdoll
Mucopolysaccharidosis Type I (MPS I)
Mucopolysaccharidosis Type VI (MPS VI), Typical Form
Mucopolysaccharidosis Type VII (MPS VII)
Myotonia Congenita
Niemann-Pick C1, NPC Disease, or Sphingomyelinosis NPC1 Mutation
Niemann-Pick C2, NPC Disease, or Sphingomyelinosis NPC2 Mutation
Periodic Hypokalemic Polymyopathy, Burmese Hypokalemia, or Familial Episodic Hypokalaemic Polymyopathy
Polycystic Kidney Disease (PKD)
Progressive Retinal Atrophy – Retinal Dystrophy (rdAc)
Vitamin D-Dependent Rickets (VDDR-1A)




Can the results be transferred to my breed registry?

DNA profiling is the primary type of DNA testing offered by breed registries in the US. DNA profiling is for the purpose of permanent identification of a cat (similar to a microchip) and for parentage testing; it does not screen for genetic diseases or genetic diversity. DNA profiling typically uses 9 microsatellite markers (often called STRs) to identify each cat, which are a different type of DNA marker than the one used in the Optimal Selection Feline DNA test. Because different markers are used, in significantly greater numbers, and at different locations than those used in DNA profiling, results are not equivalent or transferrable. While Optimal Selection was not designed for DNA profiling for the purposes of verifying parentage or cat identity, it does identify every cat tested as a unique and recognizable individual.

Can I test kittens?
Yes! Kittens can be tested, as their DNA results do not change with age. However, care must be taken that the dam’s or littermates’ DNA does not contaminate the sample. The process of nursing seeds the kitten’s mouth with DNA from the dam’s skin and the cells in the dam’s milk, so we do not recommend testing kittens who are still nursing. However, as soon as kittens are weaned, they can be safely tested following the usual guidelines. Optimal Selection feline profiles and accompanying results are designed to be easily shared or transferred to new owners when needed, free of charge, so an entire litter can be listed with Optimal Selection before they leave their birth home.

What breeds do you test for?

All breeds can be tested using an Optimal Selection DNA test and receive results about individual genetic health. However, certain breed statistics will not become available until a minimum number of individuals of that breed have been tested, in order to provide statistically significant population results.

Should I test my mixed-breed cat using Optimal Selection?
No. Optimal Selection is intended for purebred cats only.

Are results shared with registries or other breeders?
No. Wisdom Health takes client confidentiality seriously and does not share testing information. Identities of submitting owners, as well as individual testing results, are not visible to anyone but the submitting owner, unless the owner chooses to share that information.

Can I submit semen from a deceased sire?
Yes. The Optimal Selection Feline Genetic Breeding Analysis test is typically performed on cheek swab DNA samples. However, semen samples are also an excellent source of DNA if the cat is not available for swabbing.  Note that a small additional laboratory processing fee is required for semen samples.

The preferred semen sample is in the form of semen straws. However, pellets, vials or tubes of semen are also acceptable. A minimum of 50 microliters of semen is required for testing, although we recommend sending at least 100 microliters to ensure a sufficient quantity for testing. The volume contained in a semen straw varies, but any fully loaded straw will have more than the minimum 50 microliter volume.

Please contact Customer Service for a step-by-step guide to submit this sample type at or 888-K9 Pet Test (597-3883) and they would be happy to help you.