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Feline Disease Detection

 
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Comprehensive Detection for 40+ Diseases

Optimal Selection™ is a unique multipurpose test. Instead of series of one-off tests for diseases and individual mutations, Optimal Selection delivers a comprehensive set of results for more than 40 genetic diseases. However, because not all gene variants cause disease in each breed, and most disease variants have not been investigated in all breeds, detailed information about the test results are provided in three categories:

  1. Disorders known to be relevant to the tested breed
  2. New potential disorders
  3. Other disorders, usually ones not found to be significant in the breed

As genetic samples are collected and new potential disorders become known, they are listed only after certain criteria have been met to suggest they may be of significance in the breed:

  • The result is verified by a secondary technology
  • Clinical confirmation is obtained

Once these criteria have been met, the condition is listed as a new potential disorder in the breed and additional follow-up and analysis is performed. In this way, Optimal Selection users—through their sample submissions—help with ongoing research, and help participate in early surveillance for disorders that may be spreading in the population.

Following is a list of diseases that are covered by Optimal Selection. Note that not every disease is applicable to every breed. Please be aware that, due to differences in laws by country, this test list applies to US customers only. For international inquiries, please contact us for more information.

Feline Disease Screenings

Blood
Erythrocyte Pyruvate Kinase (PK) Deficiency
Factor IX Deficiency Hemophilia B (two variants)
Factor XII Deficiency
 
Endocrine
Congenital Adrenal Hyperplasia
Eyes
Progressive Retinal Atrophy - Retinal Dystrophy (rdAc)
Heart
Hypertrophic Cardiomyopathy (variant originally found in Maine Coon)
Hypertrophic Cardiomyopathy (variant originally found in Ragdoll)
Immune System
Congenital Hypotrichosis with Short Life Expectancy
Kidneys / Urinary
Hyperoxaluria
Polycystic Kidney Disease (PKD)
Metabolism
Acute Intermittent Porphyria
Chylomicronemia, Lipoprotein Lipase Deficiency
Congenital Erythropoietic Porphyria
Cystinuria (two variants)
Dihydropyrimidinuria
Mucopolysaccharidosis Type I (MPS I)
Mucopolysaccharidosis Type VI (MPS VI), Typical Form
Mucopolysaccharidosis Type VII
Vitamin D-Dependent Rickets (VDDR-1A)
 
 
Muscles
Congenital Myasthenic Syndrome (CMS)
Myotonia Congenita
Periodic Hypokalemic Polymyopathy, Burmese Hypokalemia, Familial Episodic Hypokalemic Polymyopathy
Nervous System
GM1 Gangliosidosis
GM2 Gangliosidosis, Sandhoff Disease (variant originally found in Burmese)
GM2 Gangliosidosis, Sandhoff Disease (variant originally found in Japanese domestic cat)
GM2 Gangliosidosis, Sandhoff Disease (variant originally found in Korat)
GM2 Gangliosidosis (GM2A variant)
Niemann-Pick C1, NPC Disease, Sphingomyelinosis (NPC1)
Niemann-Pick C2, NPC Disease, Sphingomyelinosis (NPC2)
 
 
 
Pharmacology
Blood-Brain Barrier Dysfunction, Multi-Drug Resistance 1 (MDR1/ABCB1)